In general, plants produced in tissue culture are true-to-type and have a uniform phenotypic appearance. However in some cases, mutations can occur that result in somaclonal variation. Somaclonal variation are mutations that occur in tissue culture.

In general, the frequency of mutation increases with the age of the tissue cultures and there is a greater potential for mutation in shoots regenerated adventitiously compared to axillary shoot regeneration.

Photo showing example plants with somaclonal variation causing varied leaf colors.